Sustained release heterodisperse hydrogel systems for...

Details Sustained release heterodisperse hydrogel systems for... Sustained release heterodisperse hydrogel systems for...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 9/52 (2006.01) A61K 31/455 (2006.01)

Patent

CA 2131647

A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.

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