In vivo expression system for cellular receptors

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) C12N 15/861 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2289613

Methods and materials for expressing and assaying functional neuronal receptors in neuronal cells, including methods for detecting particular odorant ligand specificity for particular odorant receptors and methods of using such. For example, methods and materials are provided for assaying for functional odor receptors in intact nasal epithelium of mammals such as rats and mice and for using such.

La présente invention concerne des procédés et des substances destinés à exprimer et à doser des récepteurs neuronaux fonctionnels dans des cellules neuronales, notamment des procédés de détection d'une spécificité de ligand odorant particulier associée à des récepteurs odorants particuliers et des procédés d'utilisation de ceux-ci. L'invention concerne, par exemple, des procédés et des substances permettant de doser des récepteurs odorants fonctionnels dans un épithélium nasal intact de mammifères tels que des rats et des souris. L'invention concerne également la mise en oeuvre desdits procédés et l'utilisation desdites substances.

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