Treatment of myeloma bone disease with proteasomal and nf-kb...

Details Treatment of myeloma bone disease with proteasomal and nf-kb... Treatment of myeloma bone disease with proteasomal and nf-kb...

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/66 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2369420

The present invention involves the identification and use of compositions for treating myeloma bone disease. The compositions inhibit proteasomal activity and decrease the activity of the transcription factor NF-~B. Assessment of a candidate compound for its ability to inhibit production or activity of proteasomal enzymes or NF-~B provides a useful means to identify agents to treat myeloma bone disease.

L'invention concerne l'identification et l'utilisation de compositions pour le traitement du syndrome myéloprolifératif. Lesdites compositions inhibent l'activité des protéasomes et réduisent l'activité du facteur de transcription NF-~B. L'évaluation de la capacité d'un composé d'intérêt potentiel à inhiber la production ou l'activité d'enzymes protéasomes ou de NF-~B permet l'identification efficace d'agents pour le traitement du syndrome myéloprolifératif.

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