Methods for n-demethylation of morphine and tropane alkaloids

Details Methods for n-demethylation of morphine and tropane alkaloids Methods for n-demethylation of morphine and tropane alkaloids

C - Chemistry, Metallurgy

07

D

C07D 489/02 (2006.01) B01J 23/44 (2006.01) B01J 23/72 (2006.01) C07B 43/04 (2006.01)

Patent

CA 2692433

The present invention relates to a method for N-demethylation of a tertiary N- methylated heterocycle, particularly a morphine or tropane alkaloids or derivatives thereof. The method, comprises reacting said tertiary N-methylated heterocycle with a metal catalyst, for example Pd(OAc)2 or Cu(OAc)2 in the presence of an oxidizing agent such as oxygen or ammonium persulfate.

La présente invention porte sur un procédé de N-déméthylation d'un hétérocycle N-méthylé tertiaire, en particulier des alcaloïdes morphiniques ou tropaniques ou des dérivés de ceux-ci. Le procédé comprend la réaction dudit hétérocycle N-méthylé tertiaire avec un catalyseur métallique, par exemple, Pd(OAc)2 ou Cu(OAc)2, en présence d'un agent oxydant tel que l'oxygène ou le persulfate d'ammonium.

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