Solid phase quenching systems

Details Solid phase quenching systems Solid phase quenching systems

A - Human Necessities

61

K

A61K 35/14 (2006.01) C07F 9/165 (2006.01) C12N 7/06 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2345156

Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino moiety, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a solid support including at least 1 quenching moiety attached to the solid support through covalent bonds, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the solid support and the unreacted agent from the biological matrix, where the unreacted agent is attached to the solid support through covalent bonds.

L'invention concerne des procédés permettant d'inactiver des contaminants d'une matrice biologique, qui consistent à: a) mettre en contact une matrice biologique avec un agent inactivant comprenant une fraction aziridino, une partie dudit agent réagissant ainsi avec le contaminant et l'inactivant, et une partie dudit agent ne réagissant pas; b) mettre en contact le produit obtenu à l'étape a) avec un support solide comprenant au moins une fraction d'atténuation fixée au support solide par des liaisons covalentes, dans des conditions et pendant une durée suffisante permettant à l'agent n'ayant pas réagi de se lier de manière covalente à la fraction atténuante; et c) séparer le support solide et l'agent n'ayant pas réagi de la matrice biologique, ledit agent étant fixé au support solide par des liaisons covalentes.

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