Piperidine derivatives useful as modulators of chemokine...

Details Piperidine derivatives useful as modulators of chemokine... Piperidine derivatives useful as modulators of chemokine...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01) A61P 11/06 (2006.01) A61P 31/16 (2006.01) A61P 37/00 (2006.01) C07D 211/06 (2006.01) C07D 211/44 (2006.01) C07D 211/46 (2006.01) C07D 211/58 (2006.01) C07D 211/96 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2452597

The invention provides a compound of formula (I), wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR5 or N; R1 is optionally substituted aryl or optionally substituted heterocyclyl; R2 is hydrogen or C1- 6alkyl; R3 is hydrogen or optionally substituted C1-6alkyl; and R4 is alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

Cette invention concerne un composé représenté par la formule (I) dans laquelle: T est C(O) ou S(O)¿2?; W est C(O) ou S(O)¿2?; X est CH¿2?, O ou NH; Y est CR?5¿ ou N; R?1¿ est un aryle éventuellement substitué ou un hétérocyclyle éventuellement substitué; R?2¿ est hydrogène ou C¿1-6?alkyle; R?3¿ est hydrogène ou C¿1-6?alkyle éventuellement substitué; et R?4¿ est alkyle, aryle éventuellement substitué, arlakyle éventuellement substitué ou hétérodyclyle éventuellement substitué. Ces dérivés sont des modulateurs de l'activité de la chimiokine (en particulier CCR3) qui conviennent tout particulièrement bien pour le traitement de l'asthme et/ou de la rhinite.

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