Carbamate compounds as 5-ht4 receptor agonists

Details Carbamate compounds as 5-ht4 receptor agonists Carbamate compounds as 5-ht4 receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 451/04 (2006.01) A61K 31/46 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2630222

The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5- HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclsoure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5 HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

Cette invention concerne de nouveaux composés de carbamate de formule (I), dérivés de benzimidazolone-carboxamide et utilisés comme agonistes du récepteur 5-HT4. Dans ladite formule, R1, R2, R3, R4, a et b sont tels que définis dans le mémorandum descriptif. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes d'utilisation desdits composés pour traiter des maladies associées à l'activité du récepteur 5-HT4, et des méthodes et des intermédiaires utiles pour la préparation desdits composés.

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