Raman-active particles and methods of making and using them

Details Raman-active particles and methods of making and using them Raman-active particles and methods of making and using them

G - Physics

01

N

G01N 33/543 (2006.01) G01N 21/65 (2006.01) G01N 33/553 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2582524

A Raman-active particle as well as a method of making a Raman-active particle are described. The Raman-active particle includes a core particle and a coating. The coating substantially covers the core particle. A Raman-active analyte is at least partially within the coating. The method of making a Raman- active particle includes i) providing a colloidal solution comprising a core particle; ii) providing a coating or coating precursor to the colloidal solution to form a resulting solution; and iii) providing a Raman-active analyte to the resulting solution. A method of conducting an assay is also described. The method includes: i) attaching a Raman-active particle to a targeted moiety; ii) measuring the Raman spectrum of the Raman-active particle; and iii) correlating the Raman spectrum to the presence of the targeted moiety.

La présente invention concerne des particules à effet Raman et un procédé de fabrication de ces particules. Ces particules à effet Raman comprennent une particule noyau et un revêtement. Ce revêtement recouvre sensiblement la particule noyau. Un analyte à effet Raman est au moins partiellement confiné dans le revêtement. Le procédé de fabrication de particules à effet Raman consiste : (i) à prendre une solution colloïdale comprenant une particule noyau, (ii) à fournir un revêtement ou un précurseur de revêtement à cette solution colloïdale de façon à former une solution résultante et, (iii) à fournir à cet analyte à effet Raman cette solution résultante. Cette invention concerne aussi un procédé permettant de réaliser un dosage. Ce procédé consiste : (i) à attacher une particule à effet Raman à une fraction ciblée, (ii) à mesurer le spectre Raman de cette particule et, (iii) à corréler le spectre Raman à la présence de cette fraction ciblée.

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