A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 31/155 (2006.01) A61K 31/436 (2006.01) A61K 31/517 (2006.01)
Patent
CA 2626802
A process for making a solid oral dosage form that has a therapeutic compound (e.g., a poorly soluble and/or poorly compactible therapeutic compound) and a polymer. The process is accomplished by the use of an extruder. A transient plasticizer, e.g., a liquefied gas such as supercritical carbon dioxide, is added to facilitate processing of the materials. The transient plasticizer can serve to lower the viscosity of the mixture being processes and/or enhance the solubility of the therapeutic compound.
La présente invention concerne un procédé de fabrication d'une forme galénique orale solide qui contient un composé thérapeutique (p.ex., un composé thérapeutique peu soluble et/ou peu compactable) ainsi qu'un polymère. Ce procédé est mis en oeuvre en utilisant une extrudeuse. Selon cette invention, un plastifiant transitoire, p. ex. un gaz liquéfié tel que le dioxyde de carbone supercritique, est ajouté pour faciliter le traitement des matériaux. Le plastifiant transitoire peut servir à réduire la viscosité du mélange traité et/ou à accroître la solubilité du composé thérapeutique.
Fetherstonhaugh & Co.
Novartis Ag
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