Estrogenic extracts of pueraria lobata willd. ohwi of the...

Details Estrogenic extracts of pueraria lobata willd. ohwi of the... Estrogenic extracts of pueraria lobata willd. ohwi of the...

A - Human Necessities

61

K

A61K 36/488 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2698739

Extracts of various species of the Leguminosae family have estrogenic properties. For example, aqueous and ethanolic extracts of Pueraria lobata Willd. Ohwi of the Leguminosae family species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

L'invention concerne des extraits de diverses espèces de la famille Leguminosae présentant des propriétés oestrogéniques. Par exemple, des extraits aqueux et éthanoliques de Pueraria lobata Willd. Ohwi de la famille Leguminosae possèdent des propriétés oestrogéniques à la fois dans les cellules ERa+ et ERß+. Ces effets oestrogéniques sont la stimulation de l'élément de réponse aux oestrogènes /ERE), ainsi que la répression du facteur de nécrose tumorale (TNF). L'invention concerne également des méthodes de traitement des symptômes du climatère, du cancer du sein et/ou de l'utérus et de l'ostéoporose.

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