Highly active sulphonyl urea preparations exhibiting rapid...

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 31/64 (2006.01) A61K 9/14 (2006.01) A61K 31/41 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01)

Type

Patent

Patent number

CA 2173366

Description

The invention relates to highly effective preparations of sulphonylurea derivatives which release the active substance rapidly or in a controlled manner. Included here are liquid and rapid-release or modified-release solid pharmaceutical preparations which are characterised in that they contain one or more sulphonylurea derivative(s) as active substance(s), alcohol, one or more polyol(s) with the exception of polyethylene glycol and/or one or more sugar alcohol(s), previously dissolved in water or an alcohol/water mixture, an alkaline substance and optionally suitable pharmaceutically acceptable auxiliary agents and flavourings and optionally further pharmaceutically active substances. The invention also relates to a process for producing these preparations and their use to treat diabetes (diabetes mellitus).

L'invention concerne des formes de préparation de dérivés de sulfonylurées à efficacité élevée et libérant la substance active de manière rapide ou contrôlée pour le traitement du diabète. Ces produits comprennent des formes de préparations pharmaceutiques liquides ou solides et libérant la substance active rapidement ou demanière modifiée, qui sont caractérisées en ce qu'elles contiennent un ou plusieurs dérivés de sulfonylurées comme substance(s) active(s), un alcool, un ou plusieurs polyols excepté le polyéthylèneglycol, et/ou un ou plusieurs alcools de sucre, préalablement dissous dans l'eau ou dans un mélange d'alcool et d'eau, une substance à réaction alcaline, et le cas échéant des auxiliaires et des substances aromatiques appropriés compatibles avec une utilisation pharmaceutique, et également, le cas échéant, d'autres substances à action pharmaceutique. L'invention concerne également un procédé pour la production de ces préparations ainsi que leur utilisation dans le traitement du diabète sucré.

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