Compositions of less immunogenic and long-circulating...

Details Compositions of less immunogenic and long-circulating... Compositions of less immunogenic and long-circulating...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 38/17 (2006.01) A61K 38/36 (2006.01)

Patent

CA 2660310

Provided are lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.

L'invention concerne des particules lipidiques qui comprennent la phosphatidyl choline, le phosphatidyl inositol et le cholestérol. Elle concerne également des compositions comprenant des particules lipidiques associées à des agents thérapeutiques tels que des peptides, des polypeptides ou des protéines. Dans ces compositions, les agents thérapeutiques ont une immunogénicité réduite et/ou un temps de circulation plus long. Ces compositions peuvent être utilisées pour administration thérapeutique de peptides, de polypeptides et/ou de protéines.

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