Use of alpha-rar antagonists for inhibition of mucin secretion

Details Use of alpha-rar antagonists for inhibition of mucin secretion Use of alpha-rar antagonists for inhibition of mucin secretion

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2321935

This invention is related to the use of an RAR antagonist for the inhibition of mucin production in a mammal. Preferably, the RAR antagonist is an RAR.alpha. selective antagonist. In another aspect, this invention is related to the inhibition of mucin gene expression in a human epithelial cell by contacting the cell with an RAR antagonist, preferably an RAR.alpha. selective antagonist.

L'invention concerne l'utilisation d'un antagoniste de RAR pour l'inhibition de la production de mucine chez un mammifère. L'antagoniste de RAR est de préférence un antagoniste sélectif de RAR.alpha.. Selon un autre aspect, l'invention concerne l'inhibition de l'expression du gène de la mucine dans une cellule épithéliale humaine, par la mise en contact de la cellule avec un antagoniste de RAR, de préférence un antagoniste sélectif de RAR.alpha..

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