Piperidine derivatives as potassium channel blockers

Details Piperidine derivatives as potassium channel blockers Piperidine derivatives as potassium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2487365

The invention provides compounds of formula: (see formula I) wherein: m is 0, 1 or 2; each R1 independently represent halogen or cyano; and R2 represents H or CH3, or a pharmaceutically acceptable salt thereof. The compounds and compositions containing them are useful for the treatment of human diseases or conditions in which modulation of chemokine receptor activity is beneficial, e.g., rheumatoid arthritis, chronic obstructive pulmonary disease, asthma or multiple sclerosis.

L'invention concerne des composés de formule (I), dans laquelle m, R1 et R2 sont tels que définis dans la description, des procédés de préparations de ces composés, ainsi que des compositions pharmaceutiques les renfermant et leur utilisation en thérapie.

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