Cyclic azapeptides

Details Cyclic azapeptides Cyclic azapeptides

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) A61K 38/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2297181

The invention relates to compounds of formula (I), wherein aArg, aGly, aAsp, aX and aY have the meaning cited in Claim 1, and to the salts thereof. The inventive compounds can be used as integrin inhibitors, specially in the prophylaxis and treatment of circulatory diseases, thrombosis, infarcts, coronary heart diseases, arteriosclerosis, pathological conditions, which are maintained or propagated by angiogenesis, and in addition to tumor therapy.

L'invention concerne des composés de la formule (I) cyclo-(aArg-aGly-aAsp-aX-aY) dans laquelle aArg, aGly, aAsp, aX et aY ont les significations mentionnées dans la revendication 1, ainsi que leurs sels. Ces composés s'utilisent comme inhibiteurs d'intégrine, notamment pour assurer la prophylaxie et le traitement de maladies de la circulation, en cas de thrombose, d'infarctus, de maladies cardiaques coronariennes, d'artériosclérose, en cas d'états pathologiques entretenus ou propagés par angiogenèse et sont utilisés pour traiter des tumeurs.

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