Soluble and stable sources of tyrosine, cysteine and...

A - Human Necessities – 61 – K

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A61K 38/05 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/14 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2081023

2081023 9116067 PCTABS00007 The present invention provides soluble and/or stable sources of tyrosine, cysteine and glutamine for use in total parenteral nutrition (TPN), as well as a gradual release source of glutamic acid. In particular, these sources are gamma-glutamyltyrosine (.gamma.-GluTyr), gamma-glutamylcysteine derivatives (.gamma.-GluCys) and gamma-glutamylglutamine (.gamma.-GluGln). This invention provides TPN formulations, and methods of formulating and using such solutions containing .gamma.-GluTyr, .gamma.-GluCys and/or .gamma.-GluGln to provide adequate nutritional levels of tyrosine, cysteine or glutamine during TPN.

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