Ph-sensitive polymeric conjugates of an anthracycline drug

Details Ph-sensitive polymeric conjugates of an anthracycline drug Ph-sensitive polymeric conjugates of an anthracycline drug

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2470976

Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99 % of N- (2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15 % of units of methacryloylated .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides or their sodium salts.

La présente invention concerne des conjugués consistant en un vecteur polymère constitué de 30 à 3000 unités monomères liées en chaîne polymère, composé a) de 60% à 99% d'unités <I>N</I>-(2-hydroxypropyl)méthacrylamide, b) de 1% à 25% d'unités hydrazones méthacryloylées d'acides .alpha.-aminés, d'acides .epsilon.-aminés, d'acides aminés aromatiques ou d'oligopeptides se terminant par une molécule d'un cancérostatique à base d'anthracycline, et c) de 0,5% à 15% d'unités d'acides .alpha.-aminés méthacryloylés, d'acides .epsilon.-aminés, d'acides aminés aromatiques ou d'oligopeptides ou de leurs sels de sodium.

Affiliated with

Also associated with

Rating

Ph-sensitive polymeric conjugates of an anthracycline drug does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ph-sensitive polymeric conjugates of an anthracycline drug, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ph-sensitive polymeric conjugates of an anthracycline drug will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2003400