Piperidine and piperazine derivatives as autotaxin inhibitors

Details Piperidine and piperazine derivatives as autotaxin inhibitors Piperidine and piperazine derivatives as autotaxin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/30 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2757368

The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin in-hibitors and the use of such com-pounds for the treatment and/or pro-phylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propa-gated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

La présente invention concerne des dérivés de pipéridine et de pyrazine de formules (Ia), (Ib) et (II) comme inhibiteurs de l'autotaxine et l'utilisation de tels composés pour le traitement et/ou la prophylaxie de troubles physiologiques et/ou pathophysiologiques qui sont provoqués, médiés et/ou propagés par une augmentation du taux d'acide lysophosphatique et/ou l'activation de l'autotaxine, en particulier de différents cancers.

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