N-deacetylthiocolchicine derivatives and pharmaceutical...

Details N-deacetylthiocolchicine derivatives and pharmaceutical... N-deacetylthiocolchicine derivatives and pharmaceutical...

C - Chemistry, Metallurgy

07

C

C07C 323/41 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07C 323/44 (2006.01)

Patent

CA 2403110

Derivatives of N-deacetyl- thiocolchicine or of the isoster thereof of formula (I), wherein: n is an integer of 0 to 8; Y is a CH2 group or, when n is 1, can also be a group of formula NH. Compounds (I) have anti-proliferative activity.

L'invention concerne des dérivés de N-désacétyl- thiocolchicine ou de l'isostère de ce dernier, représentés par la formule (I), dans laquelle n représente un entier compris entre 0 et 8, Y représente un groupe CH2 ou, lorsque n représente 1, un groupe représenté par la formule NH. Ces composés (I) ont une activité anti-proliférative.

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