C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2672606
The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2.
La présente invention concerne un micro-ARN innovant, mir-208-2, impliqué dans des affections musculaires et cardiovasculaires. L'invention concerne également des agents oligonucléotidiques thérapeutiques (oligonucléotides anti-sens et/ou oligonucléotides à double brin tel que des ARNdb) et leur utilisation pour le traitement des affections musculaires et cardiovasculaires qui proviennent du dérèglement de mir-208-2.
Beuvink Iwan
Hall Jonathan
Mueller Matthias
Schinke-Braun Martina
Schnell Christian
Fetherstonhaugh & Co.
Novartis Ag
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