Synthetic peptides of human papillomavirus

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/025 (2006.01) A61K 39/12 (2006.01) A61K 39/385 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2166333

Peptides for conjoint use in therapy of patients having an infection caused by HPV 16 or a like human papillomavirus, or in which such an HPV has been implicated, especially cervical dysplasias said peptides being from 15 to 24 amino acids long and consisting of or including the following sequences of amino acids of human papillomavirus (HPV) 16 L1 protein: (1) SEQ ID. NO: 1 = as residues 311-325, or a conservatively modified variant thereof; (2) SEQ ID. NO: 2 = as residues 321-335, or a conservatively modified variant thereof; and (3) SEQ. ID. NO: 3 = as residues 331-345, or a conservatively modified variant thereof. Compositions of these three peptides per se or for use in such therapy are included in the invention.

L'invention concerne des peptides s'utilisant conjointement dans des méthodes thérapeutiques s'appliquant à des patients ayant une infection due au VPH 16 ou à un virus du papillome humain analogue, ou chez lesquels ce type de virus, VPH, a été incriminé, notamment les dysplasies cervicales, ces peptides ayant une longueur de 15 à 24 acides aminés et se composant de ou comprenant les séquences suivantes d'acides aminés de la protéine L1 du virus du papillome humain (VPH) 16: (1) NO. d'identification de séquence: 1 = restes aa 311-325, ou une variante modérément modifiée de celle-ci; (2) NO. d'identification de séquence: 2 = restes aa 321-335, ou une variante modérément modifiée de celle-ci; et (3) NO. d'identification de séquence: 3 = restes aa 331-345, ou une variante modérément modifée de celle-ci. Les compositions de ces trois peptides en soi ou s'utilisant dans cette thérapie sont également décrites dans l'invention.

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