Use of neomycin for treating angiogenesis-related diseases

Details Use of neomycin for treating angiogenesis-related diseases Use of neomycin for treating angiogenesis-related diseases

A - Human Necessities

61

K

A61K 31/37 (2006.01) A61K 31/436 (2006.01) A61K 31/7036 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2331620

The present invention is directed to using neomycin or an analogue thereof as a therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells. The present invention is also directed to pharmaceutical compositions comprising: (a) neomycin or an analogue and, optionally, (b) another anti-angiogenic agent or an anti-neoplastic agent. The present invention is further directed to a method for screening neomycin analogues having anti-angiogenic activity. A preferred embodiment of the invention relates to using neomycin to treat subjects having such diseases.

L'invention concerne l'utilisation de néomycine ou d'un analogue comme agent thérapeutique pour traiter des maladies associées à l'angiogenèse, lesquelles se caractérisent par une angiogenèse excessive, indésirable ou inappropriée ou par une prolifération de cellules endothéliales. L'invention concerne également des compositions pharmaceutiques contenant: (a) de la néomycine ou un analogue et éventuellement (b) un autre agent anti-angiogénique ou anti-néoplasique. L'invention concerne également une méthode de criblage des analogues de la néomycine qui présentent une activité anti-angiogénique. Un mode de réalisation préféré concerne l'utilisation de la néomycine pour le traitement de patients souffrant des maladies susnommées.

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