Spiro-isoquinoline-pyrrolidines and analogs thereof useful...

Details Spiro-isoquinoline-pyrrolidines and analogs thereof useful... Spiro-isoquinoline-pyrrolidines and analogs thereof useful...

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2042113

This invention relates to spiro-isoquinoline-pyrrolidines having the structural formula (I) and their pharmaceutically acceptable salts thereof. (see formula I) wherein R1 and R2 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl, nitro, aryl or aryl(lower alkyl)oxy wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms; and R3 is hydrogen, alkyl containing 1 to 6 carbon atoms, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl, nitro, aryl or aryl(lower alkyl)oxy wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 5 carbon atoms. The invention also relates to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.

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