C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/222, 260/259
C07D 403/04 (2006.01) A61K 31/505 (2006.01) C07D 239/42 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2024572
This invention relates to N-heteroaryl-4-pyrimidinamines of the formula (see formula I) where R1 is hydrogen, loweralkyl, aryl, ar arylloweralkyl; R2 and R3 are independently hydrogen or loweralkyl, or R2 and R3 taken together are aryl; R4 and R5 are independently hydrogen or loweralkyl, or R4 and R5 taken together are aryl; X is hydrogen, halogen, cyano; nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or (see formula II), where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.
Davis Larry
Effland Richard Charles
Klein Joseph Thomas
Olsen Gordon Edward
Aventis Holdings Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst-Roussel Pharmaceuticals Inc.
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