Npc1l1 (npc3) and methods of use thereof

Details Npc1l1 (npc3) and methods of use thereof Npc1l1 (npc3) and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12P 21/02 (2006.01) G01N 33/567 (2006.01) G01N 33/58 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2492017

The present invention provides rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.

La présente invention concerne les polypeptides NPC1L1 de rat et de souris ainsi que des polynucléotides codant les polypeptides. L'invention concerne également des procédés de détection d'agonistes et d'antagonistes de NPC1L1. Des inhibiteurs de NPC1L1 peuvent être utilisés pour inhiber l'absorption intestinale du cholestérol chez un sujet.

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