Single chain antibodies against beta-amyloid peptide

Details Single chain antibodies against beta-amyloid peptide Single chain antibodies against beta-amyloid peptide

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2619725

Anti-A~P scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-A~p scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-A~P scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.

L'invention concerne la production d'anticorps scFv anti-A.beta.P et à domaine unique. Ces anticorps, lorsqu'ils sont présentés sur un phage filamenteux ou comme molécules de protéine soluble stabilisées par la protéine de liaison au maltose, empêchent la formation de fibrilles d'A.beta.p 1-40 et désagrègent les fibrilles d'A.beta.p 1-40 produits in vitro. De plus, les anticorps scFv anti-A.beta.p colorent les plaques séniles amyloïdes sur des coupes de souris transgéniques. Les anticorps scFv anti-A.beta.P et à domaine unique peuvent servir à inhiber ou à traiter la maladie d'Alzheimer.

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