Transdermal device containing polyvinylpyrrolidone as...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61F 13/02 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) C09J 139/06 (2006.01) C09J 183/04 (2006.01)

Patent

CA 2180530

A blend of at least three polymers, including a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. Soluble polyvinylpyrrolidone increases the solubility of drug without negatively affecting the adhesivity of the composition or the rate of drug delivery from the pressure-sensitive adhesive composition.

Un mélange d'au moins trois polymères, y compris une polyvinylpyrrolidone soluble, combiné à un médicament, permet d'obtenir une composition auto-adhésive s'utilisant dans un système transdermique d'administration de médicament, dans lequel le médicament est libéré de ladite composition auto-adhésive à travers le derme, quand ladite composition est en contact avec l'épiderme. La polyvinylpyrrolidone soluble augmente la solubilité du médicament sans exercer d'effets contraires sur les propriétés adhésives de la composition ou sur la vitesse de libération du médicament de ladite composition.

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