C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07H 21/04 (2006.01) C12N 9/64 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2291482
The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.
La présente invention a trait à une nouvelle protéine, la protéase du type activateur tissulaire du plasminogène (t-PALP), qui fait partie de la famille "sérine protéase". L'invention concerne en particulier des molécules d'acides nucléiques isolées codant la protéine t-PALP humaine. L'invention concerne en outre les polypeptides t-PALP, ainsi que les vecteurs, les cellules hôtes et les procédés recombinants de production de la t-PALP. Par ailleurs, l'invention se rapporte à des procédés de criblage permettant d'identifier les agonistes et antagonistes de l'activité de la t-PALP. L'invention concerne enfin des procédés de diagnostic, permettant de déceler des troubles liés au système circulatoire, et des procédés thérapeutiques permettant de traiter lesdits troubles.
Ebner Reinhard
Moore Paul A.
Ruben Steven M.
Gowling Lafleur Henderson Llp
Human Genome Sciences Inc.
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