A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 31/42 (2006.01) A61K 31/43 (2006.01) A61K 31/47 (2006.01) A61K 31/545 (2006.01) A61K 31/65 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2341650
The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other .beta.-lactams, which are useful in treating and preventing enterococcal infections. The combinations have anti-PBP5 activity as well as activity against the critical PBPs of sensitive isolates. The antibacterial compositions of the present invention thus comprise an important contribution to therapy for treating infections caused by these difficult to control pathogens. This combination is also useful against gram positive microorganisms, especially methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).
L'invention concerne la combinaison de nouveaux agents antibactériens 2-(naphtosultamyl)méthyl-carbapenems ou leurs sels pharmaceutiquement acceptables et d'autres .beta.-lactames. Cette combinaison convient au traitement et à la prévention des infections aux entérocoques et exerce une activité anti-PBP5 ainsi qu'une activité contre les PBP (protéines fixatrices de pénicilline) critiques des isolats sensibles. Par conséquent, ces compositions antibactériennes constituent une contribution importante au traitement des infections dues à ces pathogènes difficiles à éradiquer. Cette combinaison convient également à la lutte contre les micro-organismes Gram positifs, notamment le Staphylococcus aureus résistant à la méthicilline (MRSA), le Staphylococcus epidermidis résistant à la méthicilline (MRSE) et les staphylocoques coagulase-négatifs résistants à la méthicilline (MRCNS).
Dorso Karen L.
Gill Charles J.
Jackson Jesse J.
Kohler Joyce
Silver Lynn L.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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