C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) C12N 15/18 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2561978
This present invention discloses nucleic acid compositions and methods that are useful for treating ischemic conditions in animals, particularly in mammals such as humans. Specifically, the invention discloses nucleic acid molecules comprising or encoding a sequence that modulates the stability of a transcript from a vascular endothelial growth factor gene, as well as pharmaceutical compositions containing such molecules, which are useful for modulating angiogenesis or vascularization, especially in methods for treating ischemic conditions.
L'invention concerne des compositions et des procédés d'acides nucléiques qui sont utilisés pour traiter des états pathologiques ischémiques chez les animaux, en particulier les mammifères tels que des humains. De manière plus spécifique, l'invention concerne des molécules d'acides nucléiques comprenant ou codant une séquence qui module la stabilité d'un transcrit d'un gène de facteur de croissance endothéliale vasculaire, ainsi que des compositions pharmaceutiques contenant lesdites molécules, qui sont utilisées pour moduler l'angiogenèse ou la vascularisation, en particulier des procédés pour traiter des états pathologiques ischémiques.
Marano Robert Jeffery
Rakoczy Elizabeth Piroska
Fetherstonhaugh & Co.
Lions Eye Institute Limited
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