C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2365909
Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
L'invention porte sur des compositions et des méthodes de dépistage et de traitement du cancer du sein. Les compositions de l'invention comprennent des séquences nucléotidiques exprimées de préférence dans un tissu mammaire cancéreux, ainsi que des polypeptides codés par ces séquences nucléotidiques. L'invention porte également sur des vaccins et des compositions pharmaceutiques contenant lesdits composés et pouvant être utilisés, par exemple, pour la prévention et le traitement du cancer du sein. Ces polypeptides peuvent également être utilisés pour la production d'anticorps utiles pour le dépistage et la surveillance de l'évolution du cancer du sein chez une patiente.
Dillon Davin C.
Frudakis Tony N.
Misher Lynda E.
Reed Steven G.
Retter Marc W.
Corixa Corporation
Gowling Lafleur Henderson Llp
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