Compound

Details Compound Compound

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2679267

The present invention provides a compound of Formula (I) or Formula (Il) wherein A is selected from CR10R11, -S(=O)2-, -NR12-,and C=O, wherein R10 and R11 independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, R12 is selected from H and hydrocarbyl; B is selected from (CR13R14)1-3, C=O, CR15R16C=O, -S(=O)2-, -NR17- and -NR18-C(=O)-, wherein each of R13, R14, R15 and R16 is independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, R17 and R18 are independently selected from H and hydrocarbyl; R1 is selected from OH, O-hydrocarbyl, O-heterohydrocarbyl, -SO2-hydrocarbyl, -CH=CH2, halogen, -OSO2NR19R20, -C(=O)-NR21R22, -NR23-C(=O)H and -NR35R36; wherein each of R19, R20, R21, R22, R23, R35 and R36 is independently is selected from H and hydrocarbyl; R2 is selected from H, -O-hydrocarbyl, -S-hydrocarbyl, hydrocarbyl, -CN, -NO2, and halogens, R3 is selected from Formula (A), Formula (B), Formula (C), Formula (D) wherein each of R4, R5, R6, R7 and R8 is independently selected from H, -OH, hydrocarbyl, -O-hydrocarbyl, -COOH or an ester thereof, halocarbyl, -O-halocarbyl, acyl, -O-acyl, -NR29-acyl, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, and halogens, R9 is selected from H and hydrocarbyl, and each R29 to R33 is independently selected from H and hydrocarbyl; and wherein two or more of R4, R5, R6, R7, R8 and R9 may together form a ring; wherein when R1 is OH and R3 is of Formula (D), (i) at least one of R4, R5, R6, R7 and R8 is independently selected from halocarbyl, -O-halocarbyl, -O-acyl, -NR29-acyl, -O- SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, and halogens, or (ii) two or more of R4, R5, R6, R7 and R8 together form a ring, or (iii) at least three of R4, R5, R6, R7 and R8 are independently selected from -OH, hydrocarbyl, -O-hydrocarbyl, halocarbyl, -O-halocarbyl, -O-acyl, -NR29-acyl, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, and halogens; wherein h is an optional bond, wherein G is CR24R25, wherein R24 and R25 independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens, or wherein when h is present G is CR24, wherein R24 is selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens; n is 0, 1 or 2, each D is independently selected from O, NR26 and CR27R28, wherein each R26 is independently selected from H and hydrocarbyl; and each R27 and R28 is independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens.

La présente invention concerne un composé de formule (I) ou de formule (II) dans lesquelles A est choisi parmi CR10R11, -S(=O)2-, -NR12-, et C=O, R10 et R11 étant indépendamment choisis parmi H, -OH, un groupe hydrocarbyle, -CN, -NO2, et des atomes d'halogène, et R12 étant choisi parmi H et un groupe hydrocarbyle; B est choisi parmi (CR13R14)1-3, C=0, CR15R16C=O, -S(=O)2-, -NR17- et -NR18-C(=O)-, chacun de R13, R14, R15 et R16 étant indépendamment choisi parmi H, -OH, un groupe hydrocarbyle, -CN, -NO2, et des atomes d'halogène, R17 et R18 étant indépendamment choisis parmi H et un groupe hydrocarbyle; R1 est choisi parmi OH, un groupe O-hydrocarbyle, O-hétérohydrocarbyle, -SO2-hydrocarbyle, -CH=CH2, un atome d'halogène, -OSO2NR19R20, -C(=O)-NR21R22, -NR23-C(=O)H et -NR35R36, chacun de R19, R20, R21, R22, R23, R35 et R36étant indépendamment choisi parmi H et un groupe hydrocarbyle; R2 est choisi parmi H, un groupe -O-hydrocarbyle, -S-hydrocarbyle, hydrocarbyle, -CN, -NO2, et des atomes d'halogène, R3 est choisi parmi la formule (A), la formule (B), la formule (C), la formule (D) dans lesquelles chacun de R4, R5, R6, R7 et R8 est indépendamment choisi parmi H, -OH, un groupe hydrocarbyle, -O-hydrocarbyle, -COOH ou un ester de celui-ci, halocarbyle, -O-halocarbyle, acyle, -O-acyle, -NR29-acyle, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, et des atomes d'halogène, R9 est choisi parmi H et un groupe hydrocarbyle, et chacun de R29 à R33 est indépendamment choisi parmi H et un groupe hydrocarbyle; et dans lesquelles deux ou plus de R4, R5, R6, R7, R8 et R9 peuvent ensemble former un cycle; R1 est OH et R3 est de formule (D), (i) au moins un de R4, R5, R6, R7 et R8 est indépendamment choisi parmi un groupe halocarbyle, -O-halocarbyle, -O-acyle, -NR29-acyle, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, et des atomes d'halogène, ou (ii) deux ou plus de R4, R5, R6, R7 et R8 forment ensemble un cycle, ou (iii) au moins trois de R4, R5, R6, R7 et R8 sont indépendamment choisis parmi -OH, un groupe hydrocarbyle, -O-hydrocarbyle, halocarbyle, -O-halocarbyle, -O-acyle, -NR29-acyle, -O-SO2NR19R20, -NR30R31, -NR32SO2R33, -CN, -NO2, et des atomes d'halogène; dans lesquelles h est une liaison facultative, dans lesquelles G est CR24R25, sb> and CR27R28, wherein each R26 is independently selected from H and hydrocarbyl; and each R27 and R28 is independently selected from H, -OH, hydrocarbyl, -CN, -NO2, and halogens.

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