Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors

Details Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/89 (2006.01) A61K 31/4425 (2006.01) A61K 31/4427 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2506297

PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R1, R2 , R3 , R7, R8, R9, R10 and R6 are as defined herein.

L'invention concerne de nouveaux composés à base d'oxyde d'azote destinés à l'inhibition de la PDE4, tels que des analogues de diphénylamine et d'aniline N-substitués. Les composés de la présente invention sont représentés par les formules générales (I-III) dans lesquelles A, B, D, R?1¿, R?2¿, R?3¿, R?7¿, R?8¿, R?9¿, R?10¿ et R?6¿ désignent des éléments définis dans la présente demande.

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