C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2389415
Described are generally immune response cDNA TZap7/A, TZap7/B and TZap7 polynucleotides encoding novel proteins involved in modulation of immune responses and antibodies recognizing said proteins. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins are described. Additionally, pharmaceutical and diagnostic compositions are provided comprising any one of the afore-described polynucleotides, vectors, proteins, or antibodies. Furthermore, methods and uses for modulating immune responses through the novel TZap protein as well as pharmaceutical compositions comprising agents which act on the TZap protein or its ligand are described. also, the use of said polynucleotides, vectors, proteins or antibodies for the preparation of diagnostic and pharmaceutical compositions for use in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided.
L'invention a trait de manière générale à des polynucléotides de TZap7/A, TZap7/B et TZap7 d'ADNc de réactions immunitaires, qui codent pour de nouvelles protéines jouant un rôle dans la modulation de réactions immunitaires, et à des anticorps reconnaissant ces protéines. De plus, l'invention concerne des vecteurs contenant les polynucléotides mentionnés et des cellules hôtes transformées à l'aide de ceux-ci, ainsi que leur utilisation dans la production des protéines définies plus haut. L'invention concerne en outre des compositions pharmaceutiques et diagnostiques contenant l'un(e) des polynucléotides, vecteurs, protéines, ou anticorps décrits. L'invention concerne aussi des procédés et des utilisations permettant de moduler des réactions immunitaires au moyen de la nouvelle protéine TZap, ainsi que des compositions pharmaceutiques contenant des agents agissant sur la protéine TZap ou son ligand. L'invention concerne également l'utilisation desdits polynucléotides, vecteurs, protéines ou anticorps pour la préparation de compositions diagnostiques et pharmaceutiques s'utilisant dans la transplantation d'organes, pour traiter des maladies auto-immunes, allergiques ou infectieuses, ou des tumeurs.
Milford Edgar L.
Utku Nalan
Goudreau Gage Dubuc
The Brigham And Women's Hospital Inc.
Utku Nalan
LandOfFree
Novel genes tzap7/a, tzap7/b and tzap7 involved in t cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel genes tzap7/a, tzap7/b and tzap7 involved in t cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel genes tzap7/a, tzap7/b and tzap7 involved in t cell... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2007569