Method and device for the non-invasive analysis of metabolic...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01)

Patent

CA 2501613

The invention relates to a method and an arrangement for the non-invasive analysis of control and regulation processes in human and animal metabolism, in order to be able to draw conclusions about specific illnesses from the changes of individual metabolism parameters. Said method can be used in preventive analyses for the early detection of cancer, inflammatory diseases, and the determination of the anti-oxidant requirement, for the treatment control of individual illness images and the routine examination of occupational groups with specific physical and psychological stress. According to the invention, biologically active substances relating to metabolism and having autofluorescence properties are selected from the native fluorescence spectrum in the wavelength range of between 287 nm and 640 nm, and are interlinked in biochemical and biophysical models, in order to describe control and regulation processes in the human body. The fluorescence spectra are detected by means of an optical measuring path consisting of a light source (5), a fibre optic cable (1) for supplying the stimulation light to the measuring site, a fibre optic cable (2) for branching off the fluorescence light to the spectrometer (6), and an evaluation computer (7).

L'invention concerne un procédé et un dispositif d'examen non invasif de processus de commande et de régulation du métabolisme humain et animal permettant de tirer des conclusions sur des maladies spécifiques à partir de modifications de différents paramètres du métabolisme. Ce procédé trouve une application dans les examens préventifs de dépistage précoce du cancer, les maladies inflammatoires et la détermination des besoins en anti-oxydants, le contrôle thérapeutique des différents tableaux de la maladie et de l'examen de routines de groupes professionnels particulièrement soumis au stress physique et psychique. Selon l'invention, on sélectionne dans le spectre de fluorescence native de la plage de longueurs d'ondes de 287 nm à 640 nm des substances biologiquement actives pertinentes en termes de métabolisme et autofluorescentes et on les lie dans des modèles biochimiques et biophysiques, pour décrire des processus de commande et de régulation de l'organisme humain. On détecte les spectres de fluorescence à l'aide d'une section optique de mesure qui comprend une source lumineuse (5), un câble optique (1) destiné à l'acheminement de la lumière d'excitation jusqu'au point de mesure, un câble optique (2) destiné à la dérivation de la lumière de fluorescence jusqu'au spectromètre (6) et un calculateur d'évaluation (7).

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