Process for sultamicillin intermediate

Details Process for sultamicillin intermediate Process for sultamicillin intermediate

C - Chemistry, Metallurgy

07

D

C07D 499/86 (2006.01) C07D 499/00 (2006.01)

Patent

CA 2078217

A simplified method for making the chloromethyl ester of sulbactam in which the tetraalkylammonium sulbactam salt is not dried and isolated prior to alkylation. The method comprises reacting a tetraalkylammonium salt and a sulbactam salt in an aqueous solution to form an aqueous solution of tetraalkylammonium sulbactam. The tetraalkylammonium sulbactam is extracted into bromochloromethane or iodochloromethane, and water is removed from the organic layer to enhance the formation of the chloromethyl ester of sulbactam. The tetraalkylammonium sulbactam is reacted with bromochloromethane or iodochloromethane in the organic layer to form the chloromethyl ester of sulbactam.

Procédé simplifié d'obtention de l'ester chlorométhyle de sulbactame dans lequel le sel de tétraalkylammonium sulbactame n'est pas séché et isolé avant alkylation. Le procédé consiste à faire réagir un sel de tétraalkylammonium et un sel de sulbactame dans une solution aqueuse afin de former une solution aqueuse de tétraalkylammonium sulbactame. On extrait le tétraalkylammonium sulbactame dans du bromochlorométhane ou du iodochlorométhane, et on élimine l'eau de la couche organique afin d'améliorer la formation de l'ester chlorométhyle de sulbactame. On fait réagir le tétraalkylammonium sulbactame avec du bromochlorométhane ou du iodochlorométhane dans la couche organique afin de former l'ester chlorométhyle de sulbactame.

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