Detection of poor metabolizers of drugs

Details Detection of poor metabolizers of drugs Detection of poor metabolizers of drugs

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 9/00 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2045012

A method for the detection of poor metabolizers of drugs using PCR technology as described comprising a) optionally amplifying a gene coding for an enzyme known to be responsible for the metabolization of drugs, thereby separating it from possible closely related pseudogens, b) amplifying different allelic forms of the gene of step a) and c) detecting the product of step b). Primers for amplification of genes coding for drug metabolizing enzymes, especially genes coding for enzymes responsible for the debrisoquine or acetylation phenotype, are also disclosed.

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