Targeted delivery of drugs for the treatment of viral...

A - Human Necessities – 61 – K

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Details

A61K 38/00 (2006.01) A61K 39/12 (2006.01) A61K 39/245 (2006.01) A61K 39/29 (2006.01) A61K 47/48 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2447335

Conjugates of transferrin or transcobalamin with anti-viral agents are useful in the treatment of viral infections. Suitable anti-viral agents include apoptosis inducing compounds, compounds which inhibit the replication of the virus, a cytotoxic antibiotic, an alkylating agent, a plant toxin, and a bacterial mutant toxin. Transferrin or transcobalamin is preferably coupled to the anti-viral agent by means of glutaraldehyde.

Cette invention porte sur des conjugués de transferrine ou de transcobalamine renfermant des agents antiviraux, lesquels conjugués sont utilisés pour traiter des infections virales. Les agents antiviraux appropriés comprennent des composés induisant l'apoptose, des composés inhibant la multiplication virale, un antibiotique cytotoxique, un agent alkylant, une phytotoxine et une toxine mutante bactérienne. La transferrine ou la transcobalamine est de préférence liée à l'agent antiviral à l'aide de glutaraldéhyde.

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