Combination of an allosteric carboxylic inhibitor of matrix...

A - Human Necessities – 61 – K

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Details

A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2495432

This invention provides a combination, comprising an allosteric carboxylic inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. This invention also provides a method of treating a disease that is responsive to inhibition of MMP-13 and cyclooxygenase2, comprising administering to a patient suffering from such a disease the invention combination comprising an allosteric carboxylic inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof. This invention also provides a pharmaceutical composition, comprising the invention combination comprising an allosteric carboxylic inhibitor of MMP-13, or a pharmaceutically acceptable salt thereof, with celecoxib, or a pharmaceutically acceptable salt thereof, or valdecoxib, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. The invention combination may also be further combined with other pharmaceutical agents depending on the disease being treated.

L'invention concerne une combinaison comprenant un inhibiteur carboxylique allostérique de MMP-13, ou un sel pharmaceutiquement acceptable de celui-ci, et du celecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci, ou du valdecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne une méthode de traitement d'une maladie réagissant à l'inhibition de MMP-13 et de la cyclooxygénase-2, consistant à administrer à un patient souffrant d'une telle maladie la combinaison de l'invention comprenant un inhibiteur carboxylique allostérique de MMP-13, ou un sel pharmaceutiquement acceptable de celui-ci, et du celecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci, ou du valdecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également une composition pharmaceutique comprenant la combinaison de l'invention, comprenant un inhibiteur carboxylique allostérique de MMP-13, ou un sel pharmaceutiquement acceptable de celui-ci, et du celecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci, ou du valdecoxibe, ou un sel pharmaceutiquement acceptable de celui-ci, et un excipient, un diluant ou un véhicule pharmaceutiquement acceptable. L'invention peut également être combinée à d'autres agents pharmaceutiques, en fonction de la maladie à traiter.

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