Novel methods and compositions involving opioids and...

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 31/4748 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2392362

Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea. Figures 2A aand 2B are graphical representations of studies on the inhibition of nausea and vomiting employing methods according to an embodiment of the present invention,

La présente invention concerne de nouveaux procédés et de nouvelles compositions comprenant des opioïdes et des antagonistes d'opioïdes. Dans des formes de réalisation préférées, les procédés et les compositions comprennent des opioïdes et des composés d'antagonistes d'opioïdes périphériques de type mu. Ces procédés et ces compositions sont tout particulièrement adaptés pour traiter et/ou prévenir les effets secondaires associés aux opioïdes tels que par exemple, la constipation, les vomissements et/ou les nausées.

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