Substituted 1,8-naphthyridines

Details Substituted 1,8-naphthyridines Substituted 1,8-naphthyridines

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2013783

ABSTRACT OF THE DISCLOSURE Inhibitors of 3-hydroxy-3-methyl-glutaryl- coenzyme A reductase which are 1,8-naphthyridines of the formula Image in which A - represents a 3- to 7-membered heterocycle which is optionally substituted, or aryl which is optionally substituted, B - represents cycloalkyl or alkyl which is optionally substituted, aryl which is optionally substituted, D and E are identical or different and - represents hydrogen, halogen, mercapto, hydroxyl, alkoxy, alkyl which is optionally substituted, or a group of the formula -NR1R2, aryl, aryloxy or arylthio having 6 to 10 carbon atoms, which is optionally substituted, Y - represents a group of the formula Image or Image in which J - denotes hydrogen, hydroxyl, mercapto or halogen, or alkyl, alkoxy or alkylthio which are option- ally substituted, aryloxy, benzyloxy or arylthio or a group of the formula -NR1R2, Z - denotes oxygen or sulphur, G - denotes hydrogen, alkyl or alkenyl which is optionally substituted, Le A 26 759 X - represents a group of the formula -CH2-CH2- or -CH=CH-, and R - represents a group of the formula Image or Image in which R5 - denotes hydrogen or alkyl, and R6 _ denotes hydrogen or alkyl, which may be substituted by phenyl, or - denotes aryl or a cation, and their salts. Le A 26 759

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