Thienopyridine derivatives, production method and use thereof

Details Thienopyridine derivatives, production method and use thereof Thienopyridine derivatives, production method and use thereof

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2566421

A compound represented by the formula (I) wherein R is a hydrogen atom or a C1- 4 alkyl group, and X is CH2, O or S, or a salt thereof. The present invention provides a novel thienopyridine derivative having an anti-inflammatory effect, a bone resorption suppressing effect, an immune cytokine production suppressing effect and the like, and useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of arthritis such as rheumatoid arthritis and the like, and the like, and the like.

Un composé représenté par la formule (I) où R est un atome d'hydrogène ou un groupe d'alkyle C¿1?-¿4? et X est du CH¿2?, O ou S ou un sel de ceux-ci. La présente invention propose un nouveau dérivé de la thiénopyridine ayant un effet anti-inflammatoire, un effet de suppression de résorption des os, un effet de suppression de la production de cytokine immune et similaire et qui est utile sous forme d'agent pharmaceutique comme agent pour la prophylaxie ou le traitement de l'arthrite, comme une arthrite rhumatoïde et similaire.

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