Herpesvirus replication defective mutants

Details Herpesvirus replication defective mutants Herpesvirus replication defective mutants

A - Human Necessities

61

K

A61K 39/245 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2180551

A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutated herpesvirus is also capable of treating immunomodulatory or immunoregulatory diseases. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.

Un vaccin anti-herpès virus comprend un herpès virus ayant subi une mutation, en suspension dans un porteur pharmaceutiquement acceptable. L'herpès virus ayant muté peut infecter des cellules du mammiféres à vacciner, mais il est incapable d'effectuer complètement un cycle de réplication, tout en pouvant provoquer une réponse immunitaire protectrice dans ledit mammifère. L'herpès virus ayant muté peut également traiter des troubles immumodulateurs et immunorégulateurs. La mutation se fait dans au moins un gène codant une protéine essentielle pour la réplication du virus, de sorte que cette mutation rend le virus incapable de se répliquer.

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