C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/10 (2006.01) A61K 31/00 (2006.01) A61K 31/663 (2006.01) A61K 45/06 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2403735
The present invention relates to methods for identifying compounds useful as inhibitors of geranylgeranyl diphosphate synthase. More particularly, the compounds so identified are useful for inhibiting bone resorption. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a geranylgeranyl diphosphate synthase inhibitor.
L'invention concerne des procédés d'identification de composés servant à inhiber la géranylgéranyl diphosphate synthase. Les composés identifiés selon l'invention servent en particulier à inhiber la résorption osseuse. La présente invention concerne également des procédés d'inhibition de la résorption osseuse chez les mammifères, lesdits procédés consistant à administrer à un mammifère nécessitant un tel traitement une quantité thérapeutique efficace d'un inhibiteur de géranylgéranyl diphosphate synthase.
Reszka Alfred A.
Rodan Gideon A.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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