Modulators of bruton's tyrosine kinase and bruton's tyrosine...

Details Modulators of bruton's tyrosine kinase and bruton's tyrosine... Modulators of bruton's tyrosine kinase and bruton's tyrosine...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 38/45 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2426508

The present invention relates to the identification of Bruton's Tyrosine Kinase as a critical intermediate in the process of osteoclst activation, modulators. It is now found that such modulators are useful in the treatment and prevention of osteoporosis and related disease states.

L'invention concerne l'identification de la tyrosine kinase de Bruton comme intermédiaire critique dans le processus d'activation de l'ostéoclaste, des modulateurs de la tyrosine kinase de Bruton, ainsi que des essais d'identification de ces modulateurs. Ces modulateurs peuvent être utilisés dans le traitement et la prévention de l'ostéoporose et d'états pathologiques connexes.

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