Crystal structures of neuropilin fragments and...

Details Crystal structures of neuropilin fragments and... Crystal structures of neuropilin fragments and...

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2687556

The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications.

La présente invention concerne les structures cristallines des fragments de la neuropiline 1 (Nrp1) et de la neuropiline 2 (Nrp2) seuls ou complexés aux anticorps anti-neuropiline et les procédés pour leur utilisation. La présente invention concerne également les anticorps anti-Nrp et les procédés pour leurs applications thérapeutiques.

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