Ophthalmic compositions based on tamarind seed...

A - Human Necessities – 61 – K

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A61K 31/728 (2006.01) A61K 9/08 (2006.01) A61K 31/715 (2006.01) A61K 36/48 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2701721

The invention concerns ophthalmic solutions indicated for use as tear substitutes, containing a combination of hyaluronic acid and a polysaccharide known as TSP (Tamarindus indica Seed Polisacchahde) which are able, when administered together in a combination, to act synergistically in stimulating the return to normality of the conjunctival mucosa affected by dry eye syndrome, thus inducing a remarkable improvement in the number and morphology of the conjunctival microvilli. The ophthalmic preparations, proposed for use in the treatment of dry eye syndrome contain, in combination, from 0.05 to 2% by weight of tamarind seed polysaccharide (TSP) and from 0.05 to 1 % by weight of hyaluronic acid in aqueous solution.

L'invention concerne des solutions ophtalmiques utilisées comme larmes artificielles, qui contiennent une combinaison d'un acide hyaluronique et d'un polysaccharide connu sous le nom de TSP ("Tamarindus indica Seed Polisaccharide" ou polysaccharide de graines de tamarin) qui, lorsqu'ils sont administrés ensemble de manière combinée, exercent une action synergique stimulant le retour à la normale de la muqueuse conjonctivale atteinte du syndrome de l'oeil sec, améliorant de la sorte de façon remarquable le nombre et la morphologie des microvillosités conjonctivales. Les préparations ophtalmiques de l'invention, qui sont destinées au traitement du syndrome de l'oeil sec, contiennent, de manière combinée, de 0,05 à 2% en poids d'un polysaccharide de graines de tamarin (TSP) et de 0,05 à 15 % en poids d'un acide hyaluronique dans une solution aqueuse.

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