Tetrahydroisoquinoline derivatives

Details Tetrahydroisoquinoline derivatives Tetrahydroisoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 221/06 (2006.01) A61K 31/47 (2006.01) C07D 217/18 (2006.01) C07D 217/20 (2006.01) C07D 221/12 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2196392

The present invention relates to the use of tetrahydroisoquinoline derivatives of the general formula (see fig. I) wherein A is aryl R1 is hydrogen, hydroxy, lower alkyl, lower alkoxy, R-CO- or R-COO-, wherein R is lower alkyl; R2 is hydrogen, lower alkyl or cycloalkyl R3-R7 are hydrogen, lower alkyl, lower alkoxy, hydroxy or R3 and R4 taken together are -(CH2)n- or R6 and R7 taken together are -OCH2O- and n is 3 or 4, as well as pharmaceutically acceptable salts for the manufacture of medicaments for the control or treatment of diseases which represent therapeutic indications for NMDA receptor subtype specific blockers.

La présente invention a trait à l'utilisation de dérivés de la tétrahydroisoquinoline dont la formule générale est indiquée à la fig. I, où A est un groupement aryl, R1 est un hydrogène, un hydroxy, un alkyle inférieur, un alcoxy inférieur, R-C-O ou R-COO-, où R est un alkyle inférieur; R2 est un hydrogène, un alkyle inférieur ou un cycloalkyle, R3-R7 sont un hydrogène, un alkyle inférieur ou un alcoxy inférieur, un hydroxy ou R3 et R4 ensemble sont -(CH2)n- ou R6 et R7 ensemble sont -OCH2O- et n est égal à 3 ou 4, ainsi que des sels de qualité pharmaceutique pour la fabrication de médicaments destinés à combattre les maladies pour lesquelles on peut utiliser des bloquants spécifiques de sous-types du récepteurs NMDA.

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