Process for producing sustained-release tablets and enteric...

Details Process for producing sustained-release tablets and enteric... Process for producing sustained-release tablets and enteric...

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01)

Patent

CA 2186785

A process for producing sustained-release tablets which comprises tableting a mixture of water-insoluble cellulose or a derivative thereof, a drug and a wax and heat-treating the obtained tablets; and a process for producing sustained-release tablets and enteric tablets which comprises heat-treating a mixture of water-insoluble cellulose or a derivative thereof, a drug and a wax and tableting the mixture thus treated. The above processes can provide sustained-release tablets from which the drug is sustainedly released at a nearly constant of arbitrary rate and which can retain the drug activity for long and enteric tablets from which the drug is released not in the stomach but in the intestine.

L'invention concerne un procédé de production de comprimés à libération prolongée consistant à transformer en comprimé un mélange de cellulose insoluble dans l'eau ou bien un dérivé de celle-ci, d'un médicament ainsi que d'une cire, puis à traiter à chaud les comprimés obtenus, ainsi qu'un procédé de production de comprimés à libération prolongée et de comprimés entériques, consistant à traiter à chaud un mélange de cellulose insoluble dans l'eau ou bien un dérivé de celle-ci, d'un médicament ainsi que d'une cire, et à transformer en comprimés le mélange ainsi traité. Les procédés précités permettent d'obtenir des comprimés à libération prolongée desquels le médicament est libéré de manière prolongée avec une quasi constante de vitesse arbitraire, et lesquels peuvent conserver l'activité médicamenteuse pendant longtemps, ainsi que des comprimés entériques desquels le médicament est libéré non pas dans l'estomac mais dans l'intestin.

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