Mhc-peptide complex binding ligands

Details Mhc-peptide complex binding ligands Mhc-peptide complex binding ligands

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2476625

Disclosed are protein ligands comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable (VL) domain, wherein the proteins bind a complex comprising an MHC and a peptide, do not substantially bind the MHC in the absence of the bound peptide, and do not substantially bind the peptide in the absence of the MHC, and the peptide is a peptide fragment of gp100, MUC1, TAX, or hTERT. Also disclosed are methods of using and identifying such ligands.

Cette invention concerne des ligands de protéine comprenant un domaine variable de chaîne lourde d'immunoglobuline (VH) et un domaine variable de chaîne légère d'immunoglobuline (VL), lesquelles protéines se lient à un complexe composé d'un MHC et d'un peptide, ne se lient sensiblement pas au MHC en l'absence du peptide de liaison et ne se lient sensiblement pas au peptide en l'absence du MHC, le peptide étant un fragment peptidique de gp100, MUC1, TAX ou hTERT. Cette invention concerne également des méthodes d'utilisation et d'identification de ces ligands.

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